Recent research published in Endocrine Reviews suggests that hormones may hold the key to preventing wrinkles and reversing hair graying—offering exciting possibilities for future skincare and haircare treatments. 

Traditionally, only a few hormones—such as retinoids (retinol, tretinoin) and estrogen—have been used in clinical settings to combat skin aging. However, this new study explores a broader range of hormonal influences on skin and hair health, identifying key players that regulate connective tissue integrity, stem cell survival, and pigment retention. 

Among the most promising hormones studied: 

– Insulin-like growth factor 1 (IGF-1) and growth hormone, which support skin elasticity and collagen production. 

– Melatonin, a powerful antioxidant that may protect against UV-induced damage and oxidative stress, both major contributors to photoaging. 

– α-Melanocyte-stimulating hormone, which plays a role in skin pigmentation and hair color retention. 

The study also highlights unexpected biological effects of certain hormones on skin function and hair aging, suggesting that future treatments could go beyond conventional anti-aging creams. Researchers believe that hormonal therapies could be developed to slow down or even reverse visible signs of aging, including wrinkles, sagging skin, and premature hair greying. 

While these findings are promising, further research is needed to translate these insights into practical treatments. Scientists are now exploring how hormonal modulation could be safely integrated into skincare and haircare formulations, potentially revolutionizing the beauty industry. 

For more details, check out the full study in Endocrine Reviews

https://www.endocrine.org/news-and-advocacy/news-room/2025/hormones-may-have-therapeutic-potential-to-prevent-wrinkles-hair-graying